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Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 96-100

Immunohistochemical analysis of cytokeratin 10, cytokeratin 14, epidermal growth factor receptor, tenascin, and Ki-67 in selected odontogenic cysts

1 Department of Oral Pathology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India
2 Department of Oral Pathology, Mamata Dental College, Khammam, Telangana, India
3 Department of Oral Pathology, Saint Gregorius Dental College, Chelad, Kerala, India

Correspondence Address:
Ramya Ramadoss
Department of Oral Pathology, SRM Dental College, Ramapuram, Chennai - 600 089, Tamil Nadu
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DOI: 10.4103/0976-433X.155465

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Background: Odontogenic cysts are distinct entities and a quite common occurrence in the jaw bones. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Various molecules have been implicated to play a role in the pathogenesis of these lesions ranging from cell cycle perturbations to mutations in oncogenes and tumor suppressor genes. Materials and Methods: The role of cytokeratin (CK) 10 and 14, epidermal growth factor receptor (EGFR), tenascin and Ki-67 was studied in 5 cases of dentigerous cysts, 3 cases of odontogenic keratocysts (OKCs) (keratocystic odontogenic tumor), 3 cases of radicular cyst, 2 cases of orthokeratinized odontogenic cyst (OOC), and 2 cases of calcifying odontogenic cyst. Results: The study revealed that CK10 was significantly higher in OOC, CK14 expressed mild to intense positivity in all the odontogenic cysts. EGFR showed significant expression in OKC and tenascin expression was significantly higher in OKC. Conclusion: The study has observed the behavioral differences in the most commonly occurring odontogenic cysts. Further molecular characterization would help in better understanding.

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