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 Table of Contents  
REVIEW
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 131-134

Heat shock proteins and oral diseases


Department of Oral and Maxillofacial Pathology, Vishnu Dental College, Vishnupur, Bhimavaram, India

Date of Web Publication1-Mar-2014

Correspondence Address:
G Suresh Babu
Department of Oral and Maxillofacial Pathology, Vishnu Dental College, Vishnupur, Bhimavaram-34202, Andhra Pradesh
India
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  Abstract 

Heat shock proteins (HSPs) are substances expressed in response to elevated temperatures or other cellular stress. They are highly conserved proteins inhabiting nearly all subcellular compartments and are found in all organisms and all cell types. When a cell is stressed, oligomeric complexes disassemble and polypeptides unfold. Under these conditions, the role of HSPs is to reverse such changes and, if refolding becomes impossible, to potentially speed up the removal of such denatured proteins. Expression of HSPs is induced even under non-stress conditions, including those of the cell cycle, development, and differentiation. As oral cavity is subjected to wide range of environmental stresses like temperature variations, exposure to noxious substances and psychological disturbances, HSP's show immunomodulatory effects. In this article the role of HSPs expression in various microbial infections, autoimmune diseases, as well as in oral squamous cell carcinoma are expressed.

Keywords: Heat Shock Proteins, Heat shock factor, Chaperonin, Molecular chaperones, Conserved proteins.


How to cite this article:
Babu G S, Chalapathi K V, Ravikanth M, Kumar N G. Heat shock proteins and oral diseases. SRM J Res Dent Sci 2012;3:131-4

How to cite this URL:
Babu G S, Chalapathi K V, Ravikanth M, Kumar N G. Heat shock proteins and oral diseases. SRM J Res Dent Sci [serial online] 2012 [cited 2022 Jan 24];3:131-4. Available from: https://www.srmjrds.in/text.asp?2012/3/2/131/128057

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