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REVIEW ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 36-41

Transcutaneous electric nerve stimulation in trigeminal neuralgia: A review of literature


Department of Oral and Maxillofacial Surgery, Best Dental Science College, Madurai, Tamil Nadu, India

Date of Web Publication19-Mar-2014

Correspondence Address:
Varadarajan Usha
C 72/44, Santanam Road, Tvs Nagar, Madurai - 623 003, Tamil Nadu
India
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DOI: 10.4103/0976-433X.129071

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  Abstract 

Trigeminal neuralgia typically involves nerves supplying teeth, jaws and face of mostly older females around 35 years. A thorough investigation and proper diagnosis is a must prior to treatment for which investigations like computed tomography and magnetic resonance imaging should be done to rule out other systemic pathology. A proper history and multidisciplinary examination is a must for the same. The surgeon should have a thorough knowledge of both odontogenic and non odontogenic cause of pain to confirm the diagnosis and a diagnostic block has been enough in case of no other systemic pathology. Though the etiology is usually obscure, different treatment modalities have been tried for it viz. medicinal treatment, alcohol injection, peripheral neurectomy, rhizotomy and microvascular decompression etc. Transcutaneous electric nerve stimulation (TENS) is a safer, cheaper and promising option for management of neuralgic patients as an adjunct with the drugs used like baclofen or carbamazepine thereby reducing the dose of the drugs taken and minimizing the side-effects of the drugs. The analgesic mechanism of TENS involves gate control theory, physiological block and endogenous pain inhibitory systems. It is a noninvasive and safer adjunct to medical treatment in chronic neuralgic pain, economical and easy for both the doctor and the patient. The reduction of pain can be assessed by patient's verbal response as comparatively objective scale like visual analog scale or McGill's questionnaire could not be clinically applied. TENS cannot be considered as a sole remedy in chronic pain conditions, but as an adjunct whose effectiveness needs a continuous follow-up.

Keywords: Baclofen, carbamazepine, electrical stimulation, fothergill′s disease, McGill′s questionnaire, Tic Douloureux TIC, transcutaneous electric nerve stimulation, trigeminal neuralgia, trigger zones, visual analogue scale


How to cite this article:
Usha V. Transcutaneous electric nerve stimulation in trigeminal neuralgia: A review of literature. SRM J Res Dent Sci 2014;5:36-41

How to cite this URL:
Usha V. Transcutaneous electric nerve stimulation in trigeminal neuralgia: A review of literature. SRM J Res Dent Sci [serial online] 2014 [cited 2019 Jul 23];5:36-41. Available from: http://www.srmjrds.in/text.asp?2014/5/1/36/129071


  Introduction Top


Trigeminal neuralgia, also known as Tic Douloureux, trifacial neuralgia, or fothergill's disease typically involves the nerves supplying teeth, jaws, face and associated structures.

Historical perspective

It medical literature historical perspective has been recognized, in fact as early as the first century AD in the writings of Arateus [1] and later described by Johannes Bausch in 1672. Nicolas Andre in 1756 used the term tic Douloureux (painful spasm). In 1773, Fothergill gave a vivid description. Early treatments included bloodletting and the application of bandages containing arsenic, mercury, cobra, bee venom and other poisons. [2],[3]

Anatomical consideration

Trigeminal nerve (V cranial nerve) which is the largest sensory cranial nerve with three divisions viz. ophthalmic, maxillary, mandibular carries information relating to light touch, temperature, pain and proprioception from the face and head to the brain is affected in trigeminal neuralgia. Pain is usually referred to a main division of trigeminal nerve, but in some case more than one division.


  Epidemiology Top


The disease, typically involves older females aged <35 years and usually involves right half of the face and mostly females. No racial or ethnic risk factors exist. Patients with multiple sclerosis may develop trigeminal neuralgia as a secondary symptom.


  Etiology Top


The etiology is not fully understood. Many hypotheses being put forth indicate compression of the nerve root commonly by the superior cerebellar artery by tumors and other blood vessels. Furthermore damage to the myelin sheath can cause trigeminal pain; Traumatic accidents, unsuccessful dental work and various infections can damage the trigeminal nerve. The varicella zoster which causes herpes zoster can also cause intense pain in the trigeminal area that is difficult to treat. [4]

Other proposed etiologies are intrinsic in nature like within the nerve involving proliferative masses of myelin alternating with extreme degeneration or absence of myelin along specific neural segments. About 20% of patients with multiple sclerosis disorder in which plaques of demyelination are traversed by intact axons have trigeminal neuralgia. These plaques have been found in trigeminal neuralgia patient on autopsy. [5]


  Pathogenesis Top


Several theories exist but none explain the process completely; may be central or peripheral. Central theory is based on the similarity of trigeminal neuralgia to focal epilepsy and emphasizes the role of deafferentation (secondary to compression of the trigeminal roots or ganglion) state that the genesis of neural hyperactivity. Peripheral theories note that change in peripheral axons and myelin may lead to altered nerve sensitivity to chemical and mechanical stimuli. Calvin concluded that both mechanisms are required to produce trigeminal neuralgia. [6]


  Clinical Features Top


It is typically characterized by excruciating paroxysms of pain in the lips, gums, cheeks, or chin and rarely in distribution of ophthalmic division of the fifth cranial (trigeminal) nerve. The pain seldom lasts for a few seconds or a minute, but may be so intense, described as stabbing or lancinating or electric shocks that the patient winces, hence the term "tic". However, the spasmodic contraction of facial muscles is not seen. The paroxysms tend to recur frequently, both during day and night. [4],[7]

The pain may be so severe that many sufferers have attempted suicide to put an end to their torment. Another characteristic feature is the trigger zones which precipitate an attack when touched. These are common on vermilion border of lips, alae of nose, cheeks, around the eyes and tongue. Attacks are often triggered by cutaneous stimuli to the face or the oral cavity, which may be such minor activities as talking, chewing, brushing the teeth, or even wind blowing on the face. As a result, facial hygiene as well as a good diet may be neglected. Although 1% of the patients may eventually develop the disorder bilaterally, pain does not cross the midline during any single episode. The clinical course is characterized by exacerbations and remissions, but as the disorder progresses, remissions become shorter and exacerbations more severe. [8]

Diagnostic evaluation

No medical test exists to confirm and diagnose the case of trigeminal neuralgia. However in classic cases it is easy to diagnose with a diagnostic block of the involved nerve, which alleviates the pain.

Medical tests should be done to rule out serious medical problems including computed tomography (CT) and magnetic resonance imaging to rule out brain tumor, multiple sclerosis, or associated blood vessel pathology. Very often trigeminal neuralgia is not diagnosed properly and considering as facial pain, many teeth are extracted just to maximize the anxiety of the patient. There is no laboratory or radiological examination that will confirm the diagnosis of trigeminal neuralgia. Lesions should be ruled out and multiple sclerosis to be ruled out in younger patients. All trigeminal neuralgic patients should have a comprehensive oral, maxillofacial and otorhinolaryngologic examination to eliminate organic pathology, CT scan and cryography to rule out vascular anomalies.

As mentioned a positive response to a local anesthetic injection reinforces the clinical impression. A therapeutic response to the first line of medication confirms the diagnosis,

Differential diagnosis is made among various other diseases such as in acute dental diseases where the pain is sharp and continuous and not paroxysmal. When there is gingival recession or dentinal exposure the teeth are sensitive to thermal changes. If the pain is due to unerupted, malposed or supernumerary teeth, removal of the teeth produces a cure. Acute ear diseases can also mimic neuralgic pain but pain here is not paroxysmal but continuous. In traumatic injuries and arthritis, roentgenographic observations show positive findings. Pain from paranasal sinuses is not lancinating but is influenced by posture and other general features of illnesses along with nasal discharge. In facial herpes - presence of vesicles and history of viral illness can be elicited. Pain is not affected by alcohol injection or by resection of the posterior root. In migraine - there is a constant headache whereas trigeminal neuralgia is not associated with headache. Cranial tumors - pain distribution varies in its site. Moreover radiological changes will be seen.

Paroxysmal orofacial pains can cause diagnostic problems, especially when different clinical pictures occur simultaneously. Pain due to pulpitis, for example, may show the same characteristics as pain due to trigeminal neuralgia would. Moreover, the trigger point of trigeminal neuralgia can either be located in a healthy tooth or in the temporomandibular joint (TMJ). Neuralgic pain is distinguished into trigeminal neuralgia, glossopharyngeal neuralgia, Horton's neuralgia, cluster headache and paroxysmal hemicrania. Characteristic pain attacks resembling neuralgic pain result from well understood pathophysiological mechanisms. Consequently, adequate therapy, such as a Janetta procedure (microvascular decompression) and specific pharmacological therapy, could be a cure. [9]

Neuropathic pain is chronic, diverse in quality, difficult to localize and it occurs in the absence of obvious pathology. To avoid multiple, ineffective dental treatments, general practitioners must be familiar with the signs of nonodontogenic sources of tooth pain. [9],[10]

A straightforward diagnosis may not always be possible due to the overlapping clinical signs and symptoms of trigeminal neuralgia and atypical facial pain. [11],[12],[13],[14]


  Treatment Top


The diagnosis and treatment of facial pain remains a great challenge for oral and maxillofacial surgeons. The necessity of a multidisciplinary examination is emphasized. Misdiagnosis and multiple failed treatments were common in these patients with chronic orofacial pain. [15]

Based on patients age, life expectancy, associated medical and psychiatric conditions, compliance with medical therapy and tolerability of adverse effects there are various treatments proposed pharmacologic, surgical and finally non-invasive like transcutaneous electric nerve stimulation (TENS).

Carbamazepine an anticonvulsant being the first and best line of treatment (200 mg bd or tds) had severe side-effects such as drowsiness, fatigue, extreme exhaustion, dizziness, nausea and nystagmus, diplopia and dizziness can be minimized with use of long acting formulation of the drug. Next choice was phenytoin but if no effect has to be discontinued because of its toxicity. Baclofen was also found to be effective. Other drugs tried were oxycarbazine, Lamotrigine, gabapentin, toprimate etc.

Surgery, when indicated, must be based on a specific diagnosis that is amenable to surgical therapy. Neurosurgical treatments may help patients in whom medical therapy is unsuccessful or poorly tolerated.Surgical therapy is indicated who do not respond to medication divided into intra and extra cranial procedures which into percutaneous and open. Intracranial percutaneous techniques are radiofrequency, thermonucleolysis and anhydrous chemoneurolysis. It also included percutaneous ganglion compression. Open intracranial surgery includes sectioning of the nerve root, rhizotomy and microvascular compression. Extra cranial surgery includes percutaneous techniques such as injection of neurotoxic chemicals into the peripheral nerve branch. Extracranial open surgery includes neurectomy, nerve crushing and cryosurgery. [17],[18],[19]

TENS is a non-invasive method that has gained momentum through the success in the treatment of peripheral nerve lesions such as stump pain and phantom limb pain, acute and chronic neuralgias caused by herpes zoster and spinal cord lesions. Combination therapy of drugs with TENS for neuropathic pain produces better outcome and also could be considered safe in geriatric patients. [20]


  Discussion Top


Wall and Sweet were pioneers to promote the use of TENS for the treatment of chronic pain. Later on, it was successfully used for the pain of knee osteoarthritis, rib fractures, phantom limb pain and neuropathic pain syndromes etc. [21]

A study done by Oncel et al. found TENS more effective than non-steroidal anti-inflammatory drugs or placebo in patients with uncomplicated minor rib fractures. [22]

Fong et al. [23] advocated that the use of TENS could decrease the use of pethidine for first stage analgesia.

Mechanism of TENS

The analgesic mechanism of TENS involves gate control theory, physiological block and endogenous pain inhibitory systems:

Gate control theory

According to this theory, substantia gelatinosa of spinal cord acts as a gate control system. Activation of large myelinating fibers subserving touch, pressure, vibration is thought to facilitate pre synaptic inhibition of substantia gelatinosa cells in the dorsal horn, thus, reducing pain transmission via small unmyelinated fibers. [24]

As the frequency of stimulation increases, conduction decreases resulting in physiological block. Basbaum and Field proposed that there is a neural network including midbrain, medulla and spinal cord levels that monitors and modulates the activity of pain transmitting neurons. [25]

Woolf et al. in their study demonstrated that peripheral electrical stimulation could also excite naloxone dependent anti nociceptive mechanisms, i.e., endogenous opioid systems operating both at spinal and supraspinal levels. [26]

Kanaka et al. did a study and found that TENS was useful in reducing chronic pain. [27]

TENS produces electro-analgesia probably by one or of the following mechanisms: Presynaptic inhibition in the dorsal horn of the spinal cord, endogenous pain control (via endorphins, enkephalins and dynorphins), direct inhibition of an abnormally excited nerve and restoration of afferent input.

The intensity and the number of paroxysmal attacks were observed purely from patient's point of view since the objective methods such as visual analog scale (VAS) or McGill's questionnaire could not be clinically applied. VAS has a length of 10 cm the left end representing a pain intensity of '0' no pain in the right end and representing a pain intensity of 10 (unbearable pain) the patient had to choose a point on this scale to describe his intensity of pain. [20],[28]

McGill's pain questionnaire consists of 78 adjectives arranged in 20 groups and the patients express their pain. This questionnaire reflects 3 dimensions namely sensory, affective and evaluative. [28]

Descriptor differential scale applies psychophysical principles to clinical pain assessment. [29],[30]

Advantages of TENS

  • No Prostaglandins inhibition, since TENS controls pain by gate control mechanism.
  • Rapid and timely inhibition of pain at peak progression.
  • No adverse effects of drugs
  • Non-invasive
  • Short term treatment for 20-40 days when compared with long-term medicinal treatment.
  • No need for surgical intervention.
  • Doesn't need much expertise.
  • Can be used at home with portable machine.
  • Equally effective in post neurectomy and post injection alcohol neuralgia.


Transcutaneous electrical nerve stimulator refers to any one of a number of commercially available devices that apply a low voltage electrical impulse to the nerve system via electrodes placed on the skin, one being over painful area and the other elsewhere. A gel like prior to recording to electrocardiogram should be applied prior to the pad placement. The stimulus intensity, frequency and duration are adjusted by the patients to obtain relief from pain, the rationale being that electrical stimulation generated synchronous activity in the large fibers and their collaterals. These neural impulses go to substantia gelatinosa allowing reduction of impulses in smaller nerve fibers. This method can be used in trigeminal area.


  Complication and Contraindication Top


TENS is remarkably free from side-effects. The only common problem is related to an allergic dermatitis which the patient experience due to the adhesive tape holding the electrodes in patient. A mild erythema occur at the site of stimulation and if insufficient electrolyte gel is used a burning pricking sensation occur.

The only absolute contraindication for using TENS is in patients with pacemakers or other implanted electrical devices, which may be affected by the field generated by the modulator. It is probably best not to use TENS in patients unable to understand the controls such as young children, the mentally retarded, or patients with senile dementia. Since a sudden increase in the amplitude control can produce a highly painful muscle contraction for the same reason it is best for patients working with heavy machinery etc., not to use the stimulator.


  Summary and Conclusions Top


TENS is used in a variety of different clinical settings to treat a range of different acute and chronic pain conditions and has become popular with both patients and health professionals. [31]

The management of neuropathic pain is challenging, with medication being the first-line treatment. TENS should be considered as safe, simple and reusable first line of treatment for many pain conditions including trigeminal neuralgia, specially even, in a rural set up where technical expertise for surgical treatment is lacking and in patients in whom there are seen adverse drug reactions or they are not willing to take medicinal treatment, or cannot afford expensive surgical intervention. [32]

TENS is extremely useful in some dental procedures such as TMJ syndrome and tooth extraction; however, its use is not practical in all situations. The dentist must remember that TENS is an adjunctive form of treatment. [33],[34]

Although safe and effective pain control has been achieved using TENS in many fields of medicine, the application of this technique to dentistry remains almost unexplored. A study of the effectiveness of TENS in alleviating pre-existing orofacial pain, in providing analgesia during the primary dental treatment of these patients and as an alternative to conventional local anesthesia during cavity preparation in regular patients was examined. In approximately 80% of patients TENS successfully alleviated pre-existing orofacial pain. Primary dental treatment of these patients, however, was only possible under conventional local anesthesia. Pain induced by cavity preparation was adequately suppressed by TENS in approximately 80% of all cases. [34]

It is not a panacea for all types of pain, nor should it be used as a last resort. When applied correctly and with care, TENS is useful in the management of pain in the head and face.

Kanaka et al. did a study and proved TENS as a safer adjunct with the anticonvulsant drug used for trigeminal neuralgia. This was useful as the patient could avoid the frequency of drug and thereby drug toxicity was minimal. Further references from the net and journals do prove it is still effective as an adjunct rather than the main line of treatment in chronic neuralgic pain. [35],[36],[37],[38],[39]

In short it could be that TENS operated by distorting the functional activity of the nervous system thereby jamming one of its inputs.

TENS is a frequently applied therapy in chronic pain although evidence for effectiveness is inconclusive. Several types of TENS, based on different combinations of frequency, pulse duration and intensity, exist. The precise mechanism of action and the relevance of combinations of stimulus parameters are still unclear and do need further study and evaluation where presently the study done is minimal in practice due to cases being scattered by being referred to neurologist and scattered among the various dentists and not reported or to practitioners who misdiagnose or the patient are only under the anticonvulsant and do not properly follow. If a proper study and evaluation and a proper follow-up done, the patients might be benefitted by this non-invasive safer device for alleviating the incapacitating pain.

 
  References Top

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Abstract
Introduction
Epidemiology
Etiology
Pathogenesis
Clinical Features
Treatment
Discussion
Complication and...
Summary and Conc...
References

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