Print this page Email this page | Users Online: 350
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 251-256

Role of tumor markers in oral squamous cell carcinoma: Review of literature and future consideration


Department of Oral and Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India

Correspondence Address:
Smitha Bhat
Department of Oral and Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka
India
Login to access the Email id


DOI: 10.4103/0976-433X.114971

Rights and Permissions

Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. This article reviews the recently identified biomarkers for OSCC such as cytokeratins, p53, tumor necrosis factor alpha (TNF-α), etc., which are of great utility in early diagnosis. In addition, the biomarkers that have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. This article speaks about selected reaction monitoring (SRM) which might even be applied to monitor differential expression of tumor proteins in blood, saliva, or fresh frozen tissue materials. SRM technique may complement or possibly replace western blotting for biomarker verification and for selection of potential biomarker candidates. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients will allow clinicians to provide an early and appropriate treatment to patients without delay and also reduce the risk of recurrence of OSCC.


[FULL TEXT] [PDF]*
Print this article     Email this article
Next article
Previous article
Table of Contents

Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Citation Manager
Access Statistics
Reader Comments
Email Alert*
Add to My List*
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7211    
    Printed47    
    Emailed2    
    PDF Downloaded1630    
    Comments [Add]    
    Cited by others 2    

Recommend this journal